Hyperhidrosis dating, [Therapy of hyperhidrosis].


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One of the most troublesome disadvantages associated with this therapy is pain at the injection sites. Reconstitution of botulinum toxin A in a solution of lidocaine could be an easy alternative procedure to reduce the discomfort associated with those injections.

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However, the current recommendations are that botulinum toxin A should be reconstituted in normal saline. METHODS In a double-blind, side-by-side, controlled, randomized clinical trial, 29 patients hyperhidrosis dating injected with hyperhidrosis dating units of botulinum toxin A Botox ; Allergan Pharmaceuticals Ireland, Westport, Ireland reconstituted in lidocaine into one axilla and with the same dosage of the toxin, reconstituted in an equal volume of saline, into the other axilla.

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The patients were followed up for 8 months. Quantification of sweat production was performed by iodine-starch tests and by the patients' own rating of sweating.

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The intensity of pain associated with the botulinum toxin intracutaneous injections was self-assessed by the patients and was evaluated using a mm visual analogue scale. RESULTS Botulinum toxin A diluted in normal saline and botulinum toxin A diluted in lidocaine were similarly effective in terms of control of onset of sweat production, duration of effect and subjective percentage of mean decrease in sweating.

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Both treatments were well tolerated, and there were no lasting or severe adverse effects. However, because injections of botulinum toxin A reconstituted in lidocaine are associated with significantly reduced pain, lidocaine-reconstituted botulinum toxin A hyperhidrosis dating be preferable for treating axillary hyperhidrosis.

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